The Spreading Depolarization SIG will promote the mission of the Co-Operative Studies on Brain Injury Depolarizations (COSBID) within ISCBFM. COSBID is a research interest group focused on the causes and consequences of spreading depolarizations as a pathologic mechanism in neurologic diseases. The group started as a clinical research collaboration in 2003 and has firmly established the clinical relevance of spreading depolarizations in various forms of brain injury. COSBID has since evolved as a research interest group of both clinical and basic scientists to accelerate and harmonize bi-directional efforts in translational research. The focus on spreading depolarizations also necessarily implicates related topics of interest to ISCBFM, including blood flow and metabolism, seizures, blood-brain barrier, inflammation, and edema. The group meets on an annual basis and has broad international participation. Further information is available at

The mission of COSBID and the Spreading Depolarization SIG is to promote research and education in the clinical science of spreading depolarization monitoring, encourage collaborative efforts between clinicians and experimentalists, and advance basic science understanding of spreading depolarizations and related disease phenomena. This is accomplished through collaborative research and development, annual meetings and symposia, and outreach to new investigators.

Spreading Depolarization SIG Chair:
Jed Hartings

Planned Events:
International Conference on Spreading Depolarizations 2018 (Boca Raton, FL, USA; September 22-24, 2018).  Meeting website at 

Symposium on "Spreading depolarizations: the silent culprit of secondary injury that you’ve been missing" at the Annual Meeting of the Neurocritical Care Society (Boca Raton, FL, USA; 90 min; September 27, 2018) 

Workshop on Clinical Monitoring of Spreading Depolarizations (Neurocritical Care Society; Boca Raton, FL, USA; 4 hrs; September 25, 2018). 

International Conference on Spreading Depolarizations 2019 (Yokohama, Japan, in association with BRAIN & BRAIN PET2019; Dates TBD July, 2019).

How to Join:
Interested members - complete the information below to become involved with the Spreading Depolarization SIG. Your participation is welcome!